MovDisordV3, Main, Exploration, bibRecord, 001062

Metabolic Markers or Conditions Preceding Parkinson's Disease: A Case-Control Study

Identifieur interne : 001062 ( Main/Exploration ); précédent : 001061; suivant : 001063

Metabolic Markers or Conditions Preceding Parkinson's Disease: A Case-Control Study

Auteurs : Rodolfo Savica [États-Unis] ; Brandon R. Grossardt [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Walter A. Rocca [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0315933

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Hypertension artérielle, Diabète, Pathologie du système nerveux, Etude cas témoin, Indice masse corporelle, Cholestérol.
Wicri :
- topic : Diabète.

English descriptors

KwdEn :
- Aged, Biological Markers, Body Mass Index, Body mass index, Case control study, Case-Control Studies, Cholesterol, Cholesterol (blood), Coffee, Data Interpretation, Statistical, Diabetes Mellitus (epidemiology), Diabetes mellitus, Female, Humans, Hypertension, Hypertension (complications), Male, Medical Record Linkage, Middle Aged, Minnesota (epidemiology), Nervous system diseases, Odds Ratio, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (metabolism), Parkinson disease, Reproducibility of Results, Risk Assessment, Sex Factors, Smoking (epidemiology).
MESH :
- chemical , blood : Cholesterol.
- chemical : Biological Markers, Coffee.
- geographic , epidemiology : Minnesota.
- complications : Hypertension, Parkinson Disease.
- epidemiology : Diabetes Mellitus, Parkinson Disease, Smoking.
- metabolism : Parkinson Disease.
- Aged, Body Mass Index, Case-Control Studies, Data Interpretation, Statistical, Female, Humans, Male, Medical Record Linkage, Middle Aged, Odds Ratio, Reproducibility of Results, Risk Assessment, Sex Factors.

Abstract

Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson's disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design. We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995. Each incident case was matched by age (±1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol level, hypertension, and diabetes mellitus preceding the onset of PD (or the index year). There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cutoffs for BMI level (BMI ≥ 25 or BMI ≥ 30 kg/m²) and 3 cutoffs for cholesterol levels (>200, >250, or >300 mg/dL). Neither a diagnosis of hypertension or the documented use of antihypertensive medications was significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65-1.54; P = .99) nor was a diagnosis of diabetes mellitus or the use of glucose-lowering medications (OR, 0.77; 95% Cl, 0.37-1.57; P = .47). Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol level, hypertension, or diabetes mellitus with later development of PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539719

Affiliations:

Le document en format XML

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<term>Biological Markers</term>
<term>Body Mass Index</term>
<term>Body mass index</term>
<term>Case control study</term>
<term>Case-Control Studies</term>
<term>Cholesterol</term>
<term>Cholesterol (blood)</term>
<term>Coffee</term>
<term>Data Interpretation, Statistical</term>
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<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (metabolism)</term>
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<term>Reproducibility of Results</term>
<term>Risk Assessment</term>
<term>Sex Factors</term>
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<term>Body Mass Index</term>
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<term>Humans</term>
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<term>Diabète</term>
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<term>Etude cas témoin</term>
<term>Indice masse corporelle</term>
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<front><div type="abstract" xml:lang="en">Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson's disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design. We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995. Each incident case was matched by age (±1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol level, hypertension, and diabetes mellitus preceding the onset of PD (or the index year). There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cutoffs for BMI level (BMI ≥ 25 or BMI ≥ 30 kg/m<sup>2</sup>
) and 3 cutoffs for cholesterol levels (>200, >250, or >300 mg/dL). Neither a diagnosis of hypertension or the documented use of antihypertensive medications was significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65-1.54; P = .99) nor was a diagnosis of diabetes mellitus or the use of glucose-lowering medications (OR, 0.77; 95% Cl, 0.37-1.57; P = .47). Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol level, hypertension, or diabetes mellitus with later development of PD.</div>
</front>
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<tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name>
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<name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name>
<name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R." last="Grossardt">Brandon R. Grossardt</name>
<name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name>
<name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name>
<name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name>
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Movement Disorders (revue)

Metabolic Markers or Conditions Preceding Parkinson's Disease: A Case-Control Study

Metabolic Markers or Conditions Preceding Parkinson's Disease: A Case-Control Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.